Mouse Models of Diabetic Nephropathy: A Midstream Analysis from the Diabetic
Complications Consortium
Authors Frank C. Brosius IIIa, Charles E. Alpersb, Erwin P. Bottingerc, Matthew D.
Breyerd, ThomasM. Coffmane, Susan B. Gurleye, Raymond C. Harrisf, Masao Kakokig,
Matthias Kretzler, Edward H. Leiterh, Moshe Levii, Richard A. McIndoej, Kumar
Sharmak, Oliver Smithiesg, Katalin Susztakl, Nobuyuki Takahashig, Takamune
Submitted By Frank Brosius on 7/6/2009
Status Published
Journal Journal of the American Society of Nephrology : JASN
Year 2009
Date Published 12/1/2009
Volume : Pages 20(12) : 2503 - 2512
PubMed Reference 19729434
Abstract Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence,
a lack of reliable animal models that mimic human disease has delayed the
identification of specific factors that cause or predict diabetic nephropathy.
The Animal Models of Diabetic Complications Consortium (AMDCC) was created in
2001 by the National Institutes of Health to develop and characterize models of
diabetic nephropathy and other complications. This interim report and our online
supplement detail the progress made toward that goal, specifically in the
development and testing of murine models. Updates are provided on validation
criteria for early and advanced diabetic nephropathy, phenotyping methods, the
effect of background strain on nephropathy, current best models of diabetic
nephropathy, negative models, and views of future directions. AMDCC
investigators and other investigators in the field have yet to validate a
complete murine model of human diabetic kidney disease. Nonetheless, the
critical analysis of existing murine models substantially enhances our
understanding of this disease process.

Investigators with authorship
Erwin BottingerMount Sinai School of Medicine
Matthew BreyerJohnson & Johnson
Frank BrosiusUniversity of Arizona
Thomas CoffmanDuke University Medical Center
Raymond HarrisVanderbilt University
Matthias KretzlerUniversity of Michigan
Ed LeiterJackson Laboratory
Moshe LeviGeorgetown University
Richard McIndoeAugusta University
Kumar SharmaUniversity of California San Diego
Oliver SmithiesUniversity of North Carolina
Takamune TakahashiVanderbilt University