Probiotics, prebiotics, and the host microbiome: the science of translation.
Authors Petschow B, Doré J, Hibberd P, Dinan T, Reid G, Blaser M, Cani PD, Degnan FH,
Foster J, Gibson G, Hutton J, Klaenhammer TR, Ley R, Nieuwdorp M, Pot B, Relman
D, Serazin A, Sanders ME
Submitted By Submitted Externally on 2/7/2014
Status Published
Journal Annals of the New York Academy of Sciences
Year 2013
Date Published 12/1/2013
Volume : Pages 1306 : 1 - 17
PubMed Reference 24266656
Abstract Recent advances in our understanding of the community structure and function of
the human microbiome have implications for the potential role of probiotics and
prebiotics in promoting human health. A group of experts recently met to review
the latest advances in microbiota/microbiome research and discuss the
implications for development of probiotics and prebiotics, primarily as they
relate to effects mediated via the intestine. The goals of the meeting were to
share recent advances in research on the microbiota, microbiome, probiotics, and
prebiotics, and to discuss these findings in the contexts of regulatory
barriers, evolving healthcare environments, and potential effects on a variety
of health topics, including the development of obesity and diabetes; the
long-term consequences of exposure to antibiotics early in life to the
gastrointestinal (GI) microbiota; lactose intolerance; and the relationship
between the GI microbiota and the central nervous system, with implications for
depression, cognition, satiety, and mental health for people living in developed
and developing countries. This report provides an overview of these discussions.


Investigators with authorship
NameInstitution
Ruth LeyCornell University

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