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Publication

Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice.

Authors Patel M, Wang XX, Magomedova L, John R, Rasheed A, Santamaria H, Wang W, Tsai R, Qiu L, Orellana A, Advani A, Levi M, Cummins CL Submitted By Submitted Externally on 2/19/2014 Status Published Journal Diabetologia Year 2014 Date Published 2/1/2014 Volume : Pages 57 : 435 - 446 PubMed Reference 24201575 Abstract Liver X receptors (LXRs) a and ß are nuclear hormone receptors that are widely expressed in the kidney. They promote cholesterol efflux from cells and inhibit inflammatory responses by regulating gene transcription. Here, we hypothesised (1) that LXR deficiency would promote renal decline in a mouse model of diabetes by accelerating intraglomerular cholesterol accumulation and, conversely, (2) that LXR agonism would attenuate renal decline in diabetes.

Investigators with authorship
Name Institution Moshe Levi Georgetown University

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