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Publication

Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing.

Authors Ko SH, Nauta A, Morrison SD, Zhou H, Zimmermann A, Gurtner GC, Ding S, Longaker MT Submitted By Submitted Externally on 3/17/2014 Status Published Journal PLoS ONE Year 2011 Date Published Volume : Pages 6 : e27844 PubMed Reference 22125629 Abstract Diabetic wounds remain a major medical challenge with often disappointing outcomes despite the best available care. An impaired response to tissue hypoxia and insufficient angiogenesis are major factors responsible for poor healing in diabetic wounds. Here we show that the antimycotic drug ciclopirox olamine (CPX) can induce therapeutic angiogenesis in diabetic wounds. Treatment with CPX in vitro led to upregulation of multiple angiogenic genes and increased availability of HIF-1a. Using an excisional wound splinting model in diabetic mice, we showed that serial topical treatment with CPX enhanced wound healing compared to vehicle control treatment, with significantly accelerated wound closure, increased angiogenesis, and increased dermal cellularity. These findings offer a promising new topical pharmacologic therapy for the treatment of diabetic wounds.

Investigators with authorship
Name Institution Geoffrey Gurtner Stanford University

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