Mouse models of diabetic neuropathy.
Authors O'Brien PD, Sakowski SA, Feldman EL
Submitted By Eva Feldman on 3/17/2014
Status Published
Journal ILAR journal / National Research Council, Institute of Laboratory Animal Resources
Year 2014
Date Published 1/1/2014
Volume : Pages 54 : 259 - 272
PubMed Reference 24615439
Abstract Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes
and is associated with significant morbidity and mortality. DPN is characterized
by progressive, distal-to-proximal degeneration of peripheral nerves that leads
to pain, weakness, and eventual loss of sensation. The mechanisms underlying DPN
pathogenesis are uncertain, and other than tight glycemic control in type 1
patients, there is no effective treatment. Mouse models of type 1 (T1DM) and
type 2 diabetes (T2DM) are critical to improving our understanding of DPN
pathophysiology and developing novel treatment strategies. In this review, we
discuss the most widely used T1DM and T2DM mouse models for DPN research, with
emphasis on the main neurologic phenotype of each model. We also discuss
important considerations for selecting appropriate models for T1DM and T2DM DPN
studies and describe the promise of novel emerging diabetic mouse models for DPN
research. The development, characterization, and comprehensive neurologic
phenotyping of clinically relevant mouse models for T1DM and T2DM will provide
valuable resources for future studies examining DPN pathogenesis and novel
therapeutic strategies.

Investigators with authorship
Eva FeldmanUniversity of Michigan