Retinal ganglion cells in diabetes.
Authors Kern TS, Barber AJ
Submitted By Alistair Barber on 4/15/2014
Status Published
Journal The Journal of physiology
Year 2008
Date Published 9/15/2008
Volume : Pages 586 : 4401 - 4408
PubMed Reference 18565995
Abstract Diabetic retinopathy has long been recognized as a vascular disease that
develops in most patients, and it was believed that the visual dysfunction that
develops in some diabetics was due to the vascular lesions used to characterize
the disease. It is becoming increasingly clear that neuronal cells of the retina
also are affected by diabetes, resulting in dysfunction and even degeneration of
some neuronal cells. Retinal ganglion cells (RGCs) are the best studied of the
retinal neurons with respect to the effect of diabetes. Although investigations
are providing new information about RGCs in diabetes, including therapies to
inhibit the neurodegeneration, critical information about the function, anatomy
and response properties of these cells is yet needed to understand the
relationship between RGC changes and visual dysfunction in diabetes.

Investigators with authorship
Alistair BarberPennsylvania State University-Penn State College of Medicine