Animal Models of Diabetes-Induced Neuropathic Pain.
Authors Lee-Kubli CA, Mixcoatl-Zecuatl T, Jolivalt CG, Calcutt NA
Submitted By Nigel Calcutt on 4/15/2014
Status Published
Journal Current topics in behavioral neurosciences
Year 2014
Date Published 2/9/2014
Volume : Pages 20 : 147 - 170
PubMed Reference 24510303
Abstract Neuropathy will afflict over half of the approximately 350 million people
worldwide who currently suffer from diabetes diabetes and around one-third of
diabetic patients with neuropathy will suffer from painful symptoms that may be
spontaneous or stimulus evoked. Diabetes Diabetes can be induced in rats or mice
by genetic, dietary, or chemical means, and there are a variety of
well-characterized models of diabetic neuropathy diabetic neuropathy that
replicate either type 1 or type 2 diabetes diabetes . Diabetic rodents display
aspects of sensorimotor dysfunction such as stimulus-evoked allodynia allodynia
and hyperalgesia hyperalgesia that are widely used to model painful neuropathy.
This allows investigation of pathogenic mechanisms and development of potential
therapeutic interventions that may alleviate established pain or prevent onset
of pain.

Investigators with authorship
Nigel CalcuttUniversity of California San Diego