Diabetes Irreversibly Depletes Bone Marrow-Derived Mesenchymal Progenitor Cell
Authors Januszyk M, Sorkin M, Glotzbach JP, Vial IN, Maan Z, Rennert RC, Duscher D,
Thangarajah H, Longaker MT, Butte AJ, Gurtner GC
Submitted By Geoffrey Gurtner on 5/5/2014
Status Published
Journal Diabetes
Year 2014
Date Published 4/16/2014
Volume : Pages 63 : 3047 - 3056
PubMed Reference 24740572
Abstract Diabetic vascular pathology is largely attributable to impairments in tissue
recovery from hypoxia. Circulating progenitor cells have been postulated to play
a role in ischemic recovery and deficiencies in these cells have been well
described in diabetic patients. Here, we examine bone marrow-derived mesenchymal
progenitor cells (BM-MPCs) that have previously been shown to be important for
new blood vessel formation, and demonstrate significant deficits in the context
of diabetes. Further, we determine that this dysfunction is attributable to
intrinsic defects in diabetic BM-MPCs that are not correctable by restoring
glucose homeostasis. We identify two transcriptionally distinct subpopulations
that are selectively depleted by both type 1 and type 2 diabetes, and these
subpopulations have pro-vasculogenic expression profiles, suggesting that they
are vascular progenitor cells. These results suggest that the clinically
observed deficits in progenitor cells may be attributable to selective and
irreversible depletion of progenitor cell subsets in patients with diabetes.

Investigators with authorship
Geoffrey GurtnerStanford University
Michael JanuszykStanford University