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Publication

Diabetes Irreversibly Depletes Bone Marrow-Derived Mesenchymal Progenitor Cell Subpopulations.

Authors Januszyk M, Sorkin M, Glotzbach JP, Vial IN, Maan Z, Rennert RC, Duscher D, Thangarajah H, Longaker MT, Butte AJ, Gurtner GC Submitted By Geoffrey Gurtner on 5/5/2014 Status Published Journal Diabetes Year 2014 Date Published 4/16/2014 Volume : Pages 63 : 3047 - 3056 PubMed Reference 24740572 Abstract Diabetic vascular pathology is largely attributable to impairments in tissue recovery from hypoxia. Circulating progenitor cells have been postulated to play a role in ischemic recovery and deficiencies in these cells have been well described in diabetic patients. Here, we examine bone marrow-derived mesenchymal progenitor cells (BM-MPCs) that have previously been shown to be important for new blood vessel formation, and demonstrate significant deficits in the context of diabetes. Further, we determine that this dysfunction is attributable to intrinsic defects in diabetic BM-MPCs that are not correctable by restoring glucose homeostasis. We identify two transcriptionally distinct subpopulations that are selectively depleted by both type 1 and type 2 diabetes, and these subpopulations have pro-vasculogenic expression profiles, suggesting that they are vascular progenitor cells. These results suggest that the clinically observed deficits in progenitor cells may be attributable to selective and irreversible depletion of progenitor cell subsets in patients with diabetes.

Investigators with authorship
Name Institution Geoffrey Gurtner Stanford University Michael Januszyk Stanford University

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