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Publication

Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin.

Authors Jurczyk A, Diiorio P, Brostowin D, Leehy L, Yang C, Urano F, Harlan DM, Shultz LD, Greiner DL, Bortell R Submitted By Submitted Externally on 5/5/2014 Status Published Journal Diabetes, metabolic syndrome and obesity : targets and therapy Year 2013 Date Published Volume : Pages 6 : 493 - 499 PubMed Reference 24376359 Abstract Dipeptidyl-peptidase-4 (DPP-4) inhibitors are known to increase insulin secretion and beta cell proliferation in rodents. To investigate the effects on human beta cells in vivo, we utilize immunodeficient mice transplanted with human islets. The study goal was to determine the efficacy of alogliptin, a DPP-4 inhibitor, to enhance human beta cell function and proliferation in an in vivo context using diabetic immunodeficient mice engrafted with human pancreatic islets.

Investigators with authorship
Name Institution Leonard Shultz Jackson Laboratory

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