Insights into obesity and diabetes at the intersection of mouse and human
Authors Kebede MA, Attie AD
Submitted By Alan Attie on 8/5/2014
Status Published
Journal Trends in endocrinology and metabolism: TEM
Year 2014
Date Published 7/14/2014
Volume : Pages 25 : 493 - 501
PubMed Reference 25034129
Abstract Many of our insights into obesity and diabetes come from studies in mice
carrying natural or induced mutations. In parallel, genome-wide association
studies (GWAS) in humans have identified numerous genes that are causally
associated with obesity and diabetes, but discovering the underlying mechanisms
required in-depth studies in mice. We discuss the advantages of studying natural
variation in mice and summarize several examples where the combination of human
and mouse genetics opened windows into fundamental physiological pathways. A
noteworthy example is the melanocortin-4 receptor (MC4R) and its role in energy
balance. The pathway was delineated by discovering the gene responsible for the
Agouti mutation in mice. With more targeted phenotyping, we predict that
additional pathways relevant to human pathophysiology will be discovered.

Investigators with authorship
Alan AttieUniversity of Wisconsin-Madison