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Publication
Ventral prostate fibrosis in the Akita mouse is associated with macrophage and
fibrocyte infiltration.
Authors
Lee S, Yang G, Mulligan W, Gipp J, Bushman W
Submitted By
Wade Bushman on 8/5/2014
Status
Published
Journal
Journal of diabetes research
Year
2014
Date Published
Volume : Pages
2014 : 939053
PubMed Reference
25019092
Abstract
A higher incidence of lower urinary tract symptoms (LUTS) among diabetic men is
unexplained. Recently, prostate inflammation and fibrosis have been implicated
as major contributing factors to bladder outlet obstruction and LUTS. We
characterized the inflammatory cell infiltrate and collagen content of the
anterior, dorsal, and ventral lobes of 18-week-old DBA2J.Ins2-Akita mice (Akita)
and age-matched control mice. We performed hematoxylin and eosin staining to
score tissue injury and inflammation, picrosirius red staining to quantitate
collagen content, and immunostaining to identify monocytes/macrophages and
infiltrating fibrocytes. We observed significantly greater numbers of
monocytes/macrophages and fibrocytes specifically in the ventral prostate of the
Akita mice and found that this was associated with significant greater collagen
content specifically in the ventral prostate of the Akita mice. These
observations support the inference that diabetes elicits monocyte/macrophage
infiltration and collagen accumulation in the prostate and suggest that further
study of Akita mice may inform translational studies of diabetes in the genesis
prostatic inflammation, prostatic fibrosis, and LUTS.
Investigators with authorship
Name
Institution
Wade Bushman
University of Wisconsin-Madison
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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