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Publication

A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers.

Authors Kramer PA, Ravi S, Chacko B, Johnson MS, Darley-Usmar VM Submitted By Victor Darley-Usmar on 12/8/2014 Status Published Journal Redox biology Year 2014 Date Published Volume : Pages 2 : 206 - 210 PubMed Reference 24494194 Abstract The assessment of metabolic function in cells isolated from human blood for treatment and diagnosis of disease is a new and important area of translational research. It is now becoming clear that a broad range of pathologies which present clinically with symptoms predominantly in one organ, such as the brain or kidney, also modulate mitochondrial energetics in platelets and leukocytes allowing these cells to serve as "the canary in the coal mine" for bioenergetic dysfunction. This opens up the possibility that circulating platelets and leukocytes can sense metabolic stress in patients and serve as biomarkers of mitochondrial dysfunction in human pathologies such as diabetes, neurodegeneration and cardiovascular disease. In this overview we will describe how the utilization of glycolysis and oxidative phosphorylation differs in platelets and leukocytes and discuss how they can be used in patient populations. Since it is clear that the metabolic programs between leukocytes and platelets are fundamentally distinct the measurement of mitochondrial function in distinct cell populations is necessary for translational research.

Investigators with authorship
Name Institution Victor Darley-Usmar University of Alabama at Birmingham Richard McIndoe Augusta University

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