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Publication
Free fatty acid oxidation in insulin resistance and obesity.
Authors
Abel ED
Submitted By
E. Dale Abel on 3/4/2015
Status
Published
Journal
Heart and metabolism : management of the coronary patient
Year
2010
Date Published
9/1/2010
Volume : Pages
48 : 5 - 10
PubMed Reference
23646039
Abstract
The growing worldwide epidemic of obesity and diabetes portends a significant
increase in cardiovascular disease. Obesity is associated with insulin
resistance, and there is growing evidence that these conditions independently
increase the risk of heart failure. Changes in myocardial substrate utilization
develop in obesity and insulin resistance, and are characterized by increased
fatty acid oxidation and utilization, and decreased glucose utilization. This
paper will review the evidence for altered myocardial fatty acid utilization in
obesity and insulin resistance, review mechanisms that are responsible, and
discuss the relative contributions of systemic and myocardial insulin resistance
in the regulation of fatty acid utilization in the heart.
Investigators with authorship
Name
Institution
E. Dale Abel
University of Iowa
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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