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Publication
Differential roles of cardiomyocyte and macrophage peroxisome
proliferator-activated receptor gamma in cardiac fibrosis.
Authors
Caglayan E, Stauber B, Collins AR, Lyon CJ, Yin F, Liu J, Rosenkranz S, Erdmann
E, Peterson LE, Ross RS, Tangirala RK, Hsueh WA
Submitted By
Willa Hsueh on 3/4/2015
Status
Published
Journal
Diabetes
Year
2008
Date Published
9/1/2008
Volume : Pages
57 : 2470 - 2479
PubMed Reference
18511847
Abstract
Cardiac fibrosis is an important component of diabetic cardiomyopathy.
Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands repress
proinflammatory gene expression, including that of osteopontin, a known
contributor to the development of myocardial fibrosis. We thus investigated the
hypothesis that PPARgamma ligands could attenuate cardiac fibrosis.
Investigators with authorship
Name
Institution
Willa Hsueh
Ohio State University-Main Campus
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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