Differential roles of cardiomyocyte and macrophage peroxisome
proliferator-activated receptor gamma in cardiac fibrosis.
Authors Caglayan E, Stauber B, Collins AR, Lyon CJ, Yin F, Liu J, Rosenkranz S, Erdmann
E, Peterson LE, Ross RS, Tangirala RK, Hsueh WA
Submitted By Willa Hsueh on 3/4/2015
Status Published
Journal Diabetes
Year 2008
Date Published 9/1/2008
Volume : Pages 57 : 2470 - 2479
PubMed Reference 18511847
Abstract Cardiac fibrosis is an important component of diabetic cardiomyopathy.
Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands repress
proinflammatory gene expression, including that of osteopontin, a known
contributor to the development of myocardial fibrosis. We thus investigated the
hypothesis that PPARgamma ligands could attenuate cardiac fibrosis.


Investigators with authorship
NameInstitution
Willa HsuehOhio State University-Main Campus

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