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Publication
Non-invasive MRI of mouse models of atherosclerosis.
Authors
Weinreb DB, Aguinaldo JG, Feig JE, Fisher EA, Fayad ZA
Submitted By
Submitted Externally on 3/4/2015
Status
Published
Journal
NMR in biomedicine
Year
2007
Date Published
5/1/2007
Volume : Pages
20 : 256 - 264
PubMed Reference
17451174
Abstract
Early detection and characterization of atherosclerotic lesions susceptible to
sudden rupture and thrombosis may decrease morbidity and mortality. Plaque
development has been extensively studied using MRI in animal models of rapidly
progressing atherosclerosis. These transgenic mice develop atherosclerotic
plaques in the aortic root by 10 weeks of age and throughout the vasculature
thereafter. Transplantation of lesion-containing segments of the thoracic aorta
into wild-type mice results in nearly total reversal of atherosclerosis, making
it possible to study both progression and regression of plaques in this model.
MRI permits the non-invasive accurate assessment of atherosclerotic plaque
burden and the differentiation between the lipid and fibrous content of
individual plaques, thus providing a non-invasive approach to serially monitor
the evolution of individual plaques in the mouse models. Emergence of novel
contrast agents that target a diverse set of molecules within the plaque are now
helping to elucidate the changes at the cellular and molecular levels during
plaque progression and regression.
Investigators with authorship
Name
Institution
Edward Fisher
New York University School of Medicine
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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