Sign-up for our newsletter

Publication

The role of transforming growth factor ß1 in the regulation of blood pressure.

Authors Matsuki K, Hathaway CK, Lawrence MG, Smithies O, Kakoki M Submitted By Submitted Externally on 6/9/2015 Status Published Journal Current hypertension reviews Year 2014 Date Published Volume : Pages 10 : 223 - 238 PubMed Reference 25801626 Abstract Although human association studies suggest a link between polymorphisms in the gene encoding transforming growth factor (TGF) ß1 and differing blood pressure levels, a causative mechanism for this correlation remains elusive. Recently we have generated a series of mice with graded expression of TGFß1, ranging from approximately 10% to 300% compared to normal. We have found that blood pressure and plasma volume are negatively regulated by TGFß1. Of note, the 10% hypomorph exhibits primary aldosteronism and markedly impaired urinary excretion of water and electrolytes. We here review previous literature highlighting the importance of TGFß signaling as a natriuretic system, which we postulate is a causative mechanism explaining how polymorphisms in TGFß1 could influence blood pressure levels.

Investigators with authorship
Name Institution Oliver Smithies University of North Carolina

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing