The role of transforming growth factor ß1 in the regulation of blood pressure.
Authors Matsuki K, Hathaway CK, Lawrence MG, Smithies O, Kakoki M
Submitted By Submitted Externally on 6/9/2015
Status Published
Journal Current hypertension reviews
Year 2014
Date Published
Volume : Pages 10 : 223 - 238
PubMed Reference 25801626
Abstract Although human association studies suggest a link between polymorphisms in the
gene encoding transforming growth factor (TGF) ß1 and differing blood pressure
levels, a causative mechanism for this correlation remains elusive. Recently we
have generated a series of mice with graded expression of TGFß1, ranging from
approximately 10% to 300% compared to normal. We have found that blood pressure
and plasma volume are negatively regulated by TGFß1. Of note, the 10% hypomorph
exhibits primary aldosteronism and markedly impaired urinary excretion of water
and electrolytes. We here review previous literature highlighting the importance
of TGFß signaling as a natriuretic system, which we postulate is a causative
mechanism explaining how polymorphisms in TGFß1 could influence blood pressure

Investigators with authorship
Oliver SmithiesUniversity of North Carolina