Progenitor Cell Dysfunctions Underlie Some Diabetic Complications.
Authors Rodrigues M, Wong VW, Rennert RC, Davis CR, Longaker MT, Gurtner GC
Submitted By Geoffrey Gurtner on 7/7/2015
Status Published
Journal The American journal of pathology
Year 2015
Date Published 6/13/2015
Volume : Pages Not Specified : Not Specified
PubMed Reference 26079815
Abstract Stem cells and progenitor cells are integral to tissue homeostasis and repair.
They contribute to health through their ability to self-renew and commit to
specialized effector cells. Recently, defects in a variety of progenitor cell
populations have been described in both preclinical and human diabetes. These
deficits affect multiple aspects of stem cell biology, including quiescence,
renewal, and differentiation, as well as homing, cytokine production, and
neovascularization, through mechanisms that are still unclear. More important,
stem cell aberrations resulting from diabetes have direct implications on tissue
function and seem to persist even after return to normoglycemia. Understanding
how diabetes alters stem cell signaling and homeostasis is critical for
understanding the complex pathophysiology of many diabetic complications.
Moreover, the success of cell-based therapies will depend on a more
comprehensive understanding of these deficiencies. This review has three goals:
to analyze stem cell pathways dysregulated during diabetes, to highlight the
effects of hyperglycemic memory on stem cells, and to define ways of using stem
cell therapy to overcome diabetic complications.

Investigators with authorship
Geoffrey GurtnerStanford University