Lymphocyte roles in metabolic dysfunction: of men and mice.
Authors Ip BC, Hogan AE, Nikolajczyk BS
Submitted By Barbara Nikolajczyk on 1/25/2016
Status Published
Journal Trends in endocrinology and metabolism: TEM
Year 2015
Date Published 2/1/2015
Volume : Pages 26 : 91 - 100
PubMed Reference 25573740
Abstract Type 2 diabetes (T2D) is a metabolic disease associated with obesity-related
insulin resistance (IR) and chronic inflammation. Animal studies indicate that
IR can be caused and/or exacerbated by systemic and/or tissue-specific
alterations in lymphocyte differentiation and function. Human studies also
indicate that obesity-associated inflammation promotes IR. Nevertheless,
clinical trials with anti-inflammatory therapies have yielded modest impacts on
established T2D. Unlike mouse models, where obesity is predominantly associated
with IR, 20-25% of obese humans are metabolically healthy with high insulin
sensitivity. The uncoupling of obesity from IR in humans but not in animal
models advocates for a more comprehensive understanding of mediators and
mechanisms of human obesity-promoted IR, and better integration of knowledge
from human studies into animal experiments to efficiently pursue T2D prevention
and treatment.

Complications