Peripheral Neuropathy in Mouse Models of Diabetes.
Authors Jolivalt CG, Frizzi KE, Guernsey L, Marquez A, Ochoa J, Rodriguez M, Calcutt NA
Submitted By Nigel Calcutt on 9/28/2016
Status Published
Journal Current protocols in mouse biology
Year 2016
Date Published
Volume : Pages 6 : 223 - 55
PubMed Reference 27584552
Abstract Peripheral neuropathy is a frequent complication of chronic diabetes that most
commonly presents as a distal degenerative polyneuropathy with sensory loss.
Around 20% to 30% of such patients may also experience neuropathic pain. The
underlying pathogenic mechanisms are uncertain, and therapeutic options are
limited. Rodent models of diabetes have been used for more than 40 years to
study neuropathy and evaluate potential therapies. For much of this period,
streptozotocin-diabetic rats were the model of choice. The emergence of new
technologies that allow relatively cheap and routine manipulations of the mouse
genome has prompted increased use of mouse models of diabetes to study
neuropathy. In this article, we describe the commonly used mouse models of type
1 and type 2 diabetes, and provide protocols to phenotype the structural,
functional, and behavioral indices of peripheral neuropathy, with a particular
emphasis on assays pertinent to the human condition. © 2016 by John Wiley &
Sons, Inc.