Bone Microarchitecture in Type 1 Diabetes: It Is Complicated.
Authors Keenan HA, Maddaloni E
Submitted By Hillary Keenan on 10/7/2016
Status Published
Journal Current osteoporosis reports
Year 2016
Date Published 10/4/2016
Volume : Pages Not Specified : Not Specified
PubMed Reference 27704394
Abstract Patients with type 1 diabetes (T1DM) experience a disproportionate number of
fractures for their bone mineral density (BMD). Differences in bone
microarchitecture from those without the disease are thought to be responsible.
However, the literature is inconclusive. New studies of the microarchitecture
using three-dimensional imaging have the advantage of providing in vivo
estimates of "bone quality," rather than examining areal BMD alone. There are
drawbacks in that most studies have been done on those with less than a 30-year
duration of T1DM, and the techniques used to measure vary as do the sites
assessed. In addition to the rise in these imaging techniques, very recent
literature presents evidence of an intimate relationship between skeletal health
and vascular complications in T1DM. The following review provides an overview of
the available studies of the bone microarchitecture in T1DM with a discussion of
the burgeoning field of complications and skeletal health.

Investigators with authorship
Hillary KeenanJoslin Diabetes Center - Boston