Role of hypoxia during nephrogenesis.
Authors Hemker SL, Sims-Lucas S, Ho J
Submitted By Jacqueline Ho on 10/25/2016
Status Published
Journal Pediatric nephrology (Berlin, Germany)
Year 2016
Date Published
Volume : Pages 31 : 1571 - 7
PubMed Reference 26872484
Abstract Mammals develop in a physiologically hypoxic state, and the oxygen tension of
different tissues in the embryo is precisely controlled. Deviation from normal
oxygenation, such as what occurs in placental insufficiency, can disrupt fetal
development. Several studies demonstrate that intrauterine hypoxia has a
negative effect on kidney development. As nascent nephrons are forming from
nephron progenitors in the nephrogenic zone, they are exposed to varying oxygen
tension by virtue of the development of the renal vasculature. Thus,
nephrogenesis may be linked to oxygen tension. However, the mechanism(s) by
which this occurs remains unclear. This review focuses on what is known about
molecular mechanisms active in physiological and pathological hypoxia and their
effects on kidney development.

Investigators with authorship
Jacqueline HoChildren's Hospital of Pittsburgh of UPMC
Sunder Sims-LucasUniversity of Pittsburgh-Main Campus