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Publication

Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK.

Authors Ix JH, Sharma K Submitted By Kumar Sharma on 3/24/2010 Status Published Journal Journal of the American Society of Nephrology : JASN Year 2010 Date Published 3/1/2010 Volume : Pages 21(3) : 406 - 412 PubMed Reference 20150538 Abstract Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.

Investigators with authorship
Name Institution Kumar Sharma University of California San Diego

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing

Genes
Symbol Description Map3k14 mitogen-activated protein kinase kinase kinase 14 Adipoq adiponectin, C1Q and collagen domain containing