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Publication

Abnormalities in signaling pathways in diabetic nephropathy.

Authors Brosius FC, Khoury CC, Buller CL, Chen S Submitted By Oliver Smithies on 3/24/2010 Status Published Journal Expert review of endocrinology & metabolism Year 2010 Date Published 8/1/2010 Volume : Pages 5(1) : 51 - 64 PubMed Reference 20224802 Abstract Diabetic nephropathy (DN) is characterized by a plethora of signaling abnormalities that together ultimately result in the clinical and pathologic hallmarks of DN, namely progressive albuminuria followed by a gradual decline in glomerular filtration rate leading to kidney failure, and accompanied by podocyte loss, progressive glomerular sclerosis and, ultimately, progressive tubulointerstitial fibrosis. Over the past few years, the general understanding of the abnormalities in signaling pathways that lead to DN has expanded considerably. In this review, some of the important pathways that appear to be involved in driving this process are discussed, with special emphasis on newer findings and insights. Newer concepts regarding signaling changes in bradykinin, mTOR, JAK/STAT, MCP-1, VEGF, endothelial nitric oxide synthase, activated protein C and other pathways are discussed.

Investigators with authorship
Name Institution Frank Brosius University of Arizona

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing

Genes
Symbol Description Mcpt1 mast cell protease 1 Proc protein C Vegfa vascular endothelial growth factor A P5Ehs1 protein, Chr 5, NIEHS 1 Ccl2 chemokine (C-C motif) ligand 2 Mtor mechanistic target of rapamycin (serine/threonine kinase)