Measures of Autonomic Dysfunction in Diabetic and Idiopathic Gastroparesis.
Authors Mohammad MK, Pepper DJ, Kedar A, Bhaijee F, Familoni B, Rashed H, Cutts T, Abell
Submitted By Thomas Abell on 6/5/2017
Status Published
Journal Gastroenterology research
Year 2016
Date Published 10/1/2016
Volume : Pages 9 : 65 - 69
PubMed Reference 27785328
Abstract Gastroparesis is a condition classically characterized by delayed gastric
emptying and is associated with considerable morbidity. While the etiology of
gastroparesis remains elusive, autonomic dysfunction may play an important role,
especially as many patients with gastroparesis also have diabetes. The aim of
this study was to determine whether measures of autonomic function differ
between adults with diabetic gastroparesis (DG) and adults with idiopathic
gastroparesis (IG)., Tests of systemic autonomic function were performed among
20 adults with GD (six men and 14 women, mean age: 42 years) and 21 adults with
IG (seven men and 14 women, mean age: 37 years). Measures included vagal
cholinergics by R-R interval percentage variation (RRI-PV) and sympathetic
adrenergics by vasoconstriction to cold (VC) and postural adjustment ratio
(PAR). The two groups were compared using Wilcoxon rank sum tests and linear
regression analysis (STATA 10.0)., In univariate analysis, the following
autonomic measures differed significantly between DG and IG: VC (P = 0.004), PAR
(P = 0.045), VC + PAR (P = 0.002) and RRI-PV (P < 0.001). In multivariate
analysis (P = 0.002, R(2) = 0.55), only RRI-PV (adjusted odds ratio (aOR): 1.02,
95% confidence interval (CI): 1.01 - 1.03) differed significantly between DG and
IG patients., Vagal cholinergics are affected to a greater degree in DG compared
to IG, suggesting that impaired vagal tone is not a universal mechanism for