Urological complications of obesity and diabetes.
Authors Daneshgari F, Brown JS, Kusek JW, Nyberg LM
Submitted By Firouz Daneshgari on 3/31/2010
Status Published
Journal The Journal of urology
Year 2009
Date Published 12/1/2009
Volume : Pages 182 : S1
PubMed Reference 19846132
Abstract Diabetes mellitus is a spectrum of debilitating, costly diseases that can lead
to multiple and serious complications as well as premature death. The United
States Centers for Disease Control and Prevention estimated that in 2007, 23.6
million people or 7.8% of the population had diabetes.1 The report also
indicated that 25.9% of U.S. adults 20 years old or older had impaired fasting
glucose or pre-diabetes (35.4% of adults 60 years old or older). When this
percentage was applied to the entire U.S. population in 2007, an estimated 57
million American adults 20 years old or older had pre-diabetes, representing a
cohort likely to proceed to diabetes. At the same time, data from the most
recent National Health and Nutrition Examination Survey revealed that among men
and women the prevalence of obesity (body mass index 30 or greater) was 34% and
is increasing in prevalence.2 That the burden of diabetes and obesity is
substantial and increasing their impact on the health of the U.S. population
will become more apparent in the coming years. However, an area that has
received relatively little attention is the effect of diabetes and obesity on
urological complications.

Diabetes and obesity impact the function and structure of the lower urinary
tract including the bladder and prostate. They can lead to complications such as
urinary incontinence, poor bladder emptying, sexual dysfunction, lower urinary
tract symptoms and urinary tract infection. However, the prevalence of
urological complications of obesity and diabetes has not been included in the
Centers for Disease Control reports. Urological complications are found in up to
80% of individuals diagnosed with diabetes mellitus, a higher rate than that of
widely recognized complications such as neuropathy and nephropathy.3

In March 2009, with sponsorship from the National Institute of Diabetes and
Digestive and Kidney Diseases, a group of international investigators gathered
to discuss and identify research priorities related to urological complications
of obesity and diabetes. The articles published in this supplement to The
Journal of Urology® describe major areas of current interest. To stimulate and
accelerate research into urological complications, we asked the authors to
provide a translational view of this clinically important area. Our primary aims
were for leaders in the field to summarize current knowledge and identify new
areas of research to improve our understanding of urological complications in
men and women with obesity and/or diabetes. Emphasis was placed on proposing
next steps to enhance our ability to prevent or effectively treat urological
complications associated with diabetes and obesity. The articles in this issue
are a synthesis of the presentations and new research directions, and we hope
they provide the basis for future increased scientific research on urological
complications in men and women with obesity and/or diabetes.

Investigators with authorship
Firouz DaneshgariCase Western Reserve