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Publication
Recipes for Creating Animal Models of Diabetic Cardiovascular Disease
Authors
Willa Hsueh, E. Dale Abel, Jan L. Breslow, Nobuyo Maeda, Richard C. Davis,
Edward A. Fisher, Hayes Dansky, Donald A. McClain, Richard McIndoe, Momtaz K.
Wassef, Cristina Rabadan-Diehl, Ira J. Goldberg
Submitted By
Ira Goldberg on 9/24/2007
Status
Published
Journal
Circulation research
Year
2007
Date Published
5/25/2007
Volume : Pages
100 : 1415 - 1427
PubMed Reference
17525381
Abstract
Abstract—For more than 50 years, investigators have unsuccessfully tried to
recreate in experimental animals the cardiovascular complications of diabetes
seen in humans. In particular, accelerated atherosclerosis and dilated
cardiomyopathy, the major causes of mortality in patients with diabetes, have
been conspicuously absent in any mouse models of the disease. Under the auspices
of the NIH, the Animal Models of Diabetic Complications Consortium has worked to
address this issue. This effort has focused on the development of mouse models
because of the high level of genomic information available and the many
well-developed genetic manipulations that may be performed in mice. Importantly,
the consortium has also worked to standardize many methods to assess metabolic
and cardiovascular end points for measurement of the diabetic state and its
macrovascular complications. Finally, for maximum benefits from these animal
models in the study of atherosclerosis and of other diabetic complications, the
consortium has created a system for sharing both the animal models and the
accumulated phenotypic data with the greater scientific community.
Investigators with authorship
Name
Institution
E. Dale Abel
University of Iowa
Hayes Dansky
Columbia University
Richard Davis
University of California Los Angeles
Edward Fisher
New York University School of Medicine
Ira Goldberg
New York University School of Medicine
Nobuyo Maeda
University of North Carolina
Richard McIndoe
Augusta University
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Pediatric Endocrinology
Retinopathy
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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