Sign-up for our newsletter
MAIN
Event Calendar
Awardee Reports
ABOUT DIACOMP
Citing DiaComp
Contact
Committees
Institutions
Awardee Reports
Publications
Bioinformatics
RESOURCES
Protocols & Methods
Reagents & Resources
Mouse Diet
Breeding Schemes
Validation Criteria
IMPC / KOMP Data
Publications
Bioinformatics
CONTACT
PARTICIPANT AREA
Login
▹
Publications
▹
Home
Publication
Modelling diabetic nephropathy in mice.
Authors
Azushima K, Gurley SB, Coffman TM
Submitted By
Thomas Coffman on 11/8/2017
Status
Published
Journal
Nature reviews. Nephrology
Year
2017
Date Published
10/1/2017
Volume : Pages
Not Specified
:
Not Specified
PubMed Reference
29062142
Abstract
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in the
developed world. Accordingly, an urgent need exists for new, curative treatments
as well as for biomarkers to stratify risk of DN among individuals with diabetes
mellitus. A barrier to progress in these areas has been a lack of animal models
that faithfully replicate the main features of human DN. Such models could be
used to define the pathogenesis, identify drug targets and test new therapies.
Owing to their tractability for genetic manipulation, mice are widely used to
model human diseases, including DN. Questions have been raised, however, about
the general utility of mouse models in human drug discovery. Standard mouse
models of diabetes typically manifest only modest kidney abnormalities, whereas
accelerated models, induced by superimposing genetic stressors, recapitulate key
features of human DN. Incorporation of systems biology approaches and emerging
data from genomics and metabolomics studies should enable further model
refinement. Here, we discuss the current status of mouse models for DN, their
limitations and opportunities for improvement. We emphasize that future efforts
should focus on generating robust models that reproduce the major clinical and
molecular phenotypes of human DN.
Complications
All Complications
Bioinformatics
Bone
Cardiomyopathy
Cardiovascular
Gastro-Intestinal (GI)
Nephropathy
Neuropathy & Neurocognition
Pediatric Endocrinology
Retinopathy
Uropathy
Wound Healing
Welcome to the DiaComp Login / Account Request Page.
Email Address:
Password:
Note: Passwords are case-sensitive.
Please save my Email Address on this machine.
Not a member?
If you are a funded DiaComp investigator, a member of an investigator's lab,
or an External Scientific Panel member to the consortium, please
request an account.
Forgot your password?
Enter your Email Address and
click here.
ERROR!
There was a problem with the page:
User Info
User Confirm
Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
Citation text and image have been copied to your clipboard. You may now paste them into your document. Thank you!