Sign-up for our newsletter
MAIN
Event Calendar
Awardee Reports
ABOUT DIACOMP
Citing DiaComp
Contact
Committees
Institutions
Awardee Reports
Funding Programs
Pilot & Feasibility
Conference Support
Summer Student
Collaborative
External Funding Programs
Publications
Bioinformatics
RESOURCES
Protocols & Methods
Reagents & Resources
Mouse Diet
Breeding Schemes
Validation Criteria
IMPC / KOMP Data
Publications
Bioinformatics
FUNDING PROGRAMS
Pilot & Feasibility
Conference Support
Summer Student
Collaborative
External Funding Programs
CONTACT
PARTICIPANT AREA
Login
Request Account
▹
Publications
Publication
Temporal morphological and functional impact of complete urinary diversion on
the bladder: a model of bladder disuse in rats.
Authors
Liu G, Lin YH, Li M, Xiao N, Daneshgari F
Submitted By
Firouz Daneshgari on 8/2/2010
Status
Published
Journal
The Journal of urology
Year
2010
Date Published
11/1/2010
Volume : Pages
184 : 2179 - 2185
PubMed Reference
20850838
Abstract
PURPOSE: Urinary diversion has been used as a surgical option for some bladder
diseases. We developed a urinary diversion model in the rat and examined the
effects of urinary diversion on the bladder. MATERIALS AND METHODS: We
distributed female Sprague-Dawley® rats into age matched control, sham urinary
diversion and urinary diversion groups. Each group was subsequently evaluated 1
or 8 weeks after urinary diversion or sham operation. Diversion was done by
surgical disconnection of the ureters from the bladder and implantation to the
uterine cervix. Conscious cystometry was examined. Bladders were harvested for
histological examination and quantification of smooth muscle, urothelium and
collagen. Vaginal histology was assessed. Bladder muscarinic and purinergic
receptor expression was examined. RESULTS: All rats survived the urinary
diversion procedure. Bladder weight decreased in the diversion group. Cystometry
showed decreased intercontractile interval and voided volume in the urinary
diversion group compared to those in the control and sham operated groups.
Compliance was decreased in diverted rats. Smooth muscle and urothelium were
decreased as a percent of total bladder cross-sectional area. Collagen increased
in 1 and 8-week diverted rats vs controls. Histological examination of the
vaginal wall revealed mild swelling in 2 rats. Urinary diversion caused
decreased muscarinic 3 and ligand gated purinergic 1 receptor expression but no
change in muscarinic 2 or ligand gated purinergic 2 receptors. CONCLUSIONS:
Creating a urinary diversion model by ureterovaginostomy in the rat is feasible.
Urinary diversion causes distinct functional and morphometric bladder
alterations.
Investigators with authorship
Name
Institution
Firouz Daneshgari
Case Western Reserve
Complications
All Complications
Bioinformatics
Bone
Cardiomyopathy
Cardiovascular
Gastro-Intestinal (GI)
Nephropathy
Neuropathy & Neurocognition
Pediatric Endocrinology
Retinopathy
Uropathy
Wound Healing
Welcome to the DiaComp Login / Account Request Page.
Email Address:
Password:
Note: Passwords are case-sensitive.
Please save my Email Address on this machine.
Not a member?
If you are a funded DiaComp investigator, a member of an investigator's lab,
or an external advisor to the consortium, please
request an account.
Forgot your password?
Enter your Email Address and
click here.
ERROR!
There was a problem with the page:
User Info
User Confirm
Safari Browser Detected...
We strive to make the DiaComp site compatable with as many browsers as possible, but some of our third party tools don't work with the Safari browser.
In order to explore this site we highly recommend using the most recent versions of the following browsers:
Internet Explorer
Google Chrome
FireFox
Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
Citation text and image have been copied to your clipboard. You may now paste them into your document. Thank you!