Animal models and their use in understanding lower urinary tract dysfunction.
Authors Fry CH, Daneshgari F, Thor K, Drake M, Eccles R, Kanai AJ, Birder LA
Submitted By Firouz Daneshgari on 8/12/2010
Status Published
Journal Neurourology and urodynamics
Year 2010
Date Published 4/1/2010
Volume : Pages 29 : 603 - 608
PubMed Reference 20432320
Abstract This review will highlight appropriate animal models for the study of a number
of disorders involving changes to lower urinary tract function. A major hurdle
to the development of animal models for human lower urinary tract disorders is
that the clinical pathophysiology of the latter mostly remain idiopathic. Acute
injury/inflammation of otherwise healthy animals has often been used to study
effects on a target tissue/organ. However, these "acute" models may not
adequately address the characteristics of "chronic" visceral disorders. In
addition, the relevance of observed changes following acute injury/inflammation,
in terms of possible therapeutic targets, may not reflect that which occurs in
the human condition. We have therefore emphasized the situations when animal
models are required to investigate lower urinary tract disorders and what they
should set out to achieve. In particular we have discussed the merits and
disadvantages of a number of paradigms that set out to investigate specific
lower urinary tract disorders or situations associated with these conditions.
These include animal models of overactive bladder, stress urinary incontinence,
ageing and congenital defects of the urinary tract and bladder pain syndrome.

Investigators with authorship
Firouz DaneshgariCase Western Reserve