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Publication
Association of insulin sensitivity and glucose tolerance with the c.825C>T
variant of the G protein beta-3 subunit gene.
Authors
Kopf D, Cheng LS, Blandau P, Hsueh W, Raffel LJ, Buchanan TA, Xiang AH, Davis
RC, Rotter JI, Lehnert H
Submitted By
Richard Davis on 4/4/2011
Status
Published
Journal
Journal of diabetes and its complications
Year
2008
Date Published
5/1/2008
Volume : Pages
22 : 205 - 209
PubMed Reference
18413224
Abstract
The risk of macrovascular complications of diabetes mellitus is greatly enhanced
by the presence of high blood pressure. In addition, hypertension and diabetes
share insulin resistance as a common pathophysiological mechanism. Despite
evidence for a common molecular genetic background of insulin resistance,
glucose intolerance, and hypertension, few candidate genes have been shown to
influence all of these features simultaneously. We examined the association of
insulin sensitivity with the c.825C>T variant of the g-protein beta-3 subunit
(GNB3), a candidate gene of hypertension, in families of Mexican-American
hypertensive patients.
Investigators with authorship
Name
Institution
Richard Davis
University of California Los Angeles
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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