Tracing the footsteps of glomerular insulin signaling in diabetic kidney
Authors Chang GY, Park AS, Susztak K
Submitted By Erwin Bottinger on 5/2/2011
Status Published
Journal Kidney international
Year 2011
Date Published 4/1/2011
Volume : Pages 79 : 802 - 804
PubMed Reference 21451535
Abstract Insufficient insulin secretion and insulin resistance are hallmarks of diabetes.
Recent studies indicate that insulin plays an important role in maintaining the
glomerular filtration barrier. Mima et al. report that glomeruli of diabetic and
obese rats suffer from insulin resistance and altered insulin signaling. Protein
kinase C inhibitors are able to overcome insulin resistance, offering new hopes
for the treatment of the condition.

Investigators with authorship
Erwin BottingerMount Sinai School of Medicine