Human and murine kidneys show gender- and species-specific gene expression
differences in response to injury.
Authors Si H, Banga RS, Kapitsinou P, Ramaiah M, Lawrence J, Kambhampati G, Gruenwald A,
Bottinger E, Glicklich D, Tellis V, Greenstein S, Thomas DB, Pullman J, Fazzari
M, Susztak K
Submitted By Erwin Bottinger on 5/2/2011
Status Published
Journal PLoS ONE
Year 2009
Date Published 5/1/2009
Volume : Pages 4 : e4802
PubMed Reference 19277126
Abstract The incidence of End Stage Renal Disease (ESRD) is approximately 50% higher in
men than women. In order to understand the molecular basis of this gender
disparity, we examined sex specific gene expression patterns in control and
diseased, human and murine kidney samples. Using the Affymetrix platform we
performed comprehensive gene expression analysis on 42 microdissected human
kidney samples (glomeruli and tubules). We identified 67 genes with gender
biased expression in healthy human kidneys and 24 transcripts in diseased male
and female human kidneys. Similar analysis performed in mice using male and
female control and doxorubicin induced nephrotic syndrome kidneys identified
significantly larger number of differentially expressed transcripts. The
majority of genes showing gender biased expression either in diseased human and
murine kidneys were different from those differentially expressed in healthy
kidneys. Only 9 sexually dimorphic transcripts were common to healthy human and
murine kidneys and five showed differential regulation in both human and murine
diseased kidneys. In humans, sex biased genes showed statistical enrichment only
to sex chromosomes while in mice they were enriched to sex chromosomes and
various autosomes. Thus we present a comprehensive analysis of gender biased
genes in the kidney. We show that sexually dimorphic genes in the kidney show
species specific regulation. Our results also indicate that male and female
kidneys respond differently to injury. These studies could provide the basis for
the development of new treatment strategies for men and women with kidney
disease.


Investigators with authorship
NameInstitution
Erwin BottingerMount Sinai School of Medicine

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