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Publication

Understanding kidney disease: toward the integration of regulatory networks across species.

Authors Ju W, Brosius FC Submitted By Frank Brosius on 5/2/2011 Status Published Journal Seminars in nephrology Year 2010 Date Published 9/1/2010 Volume : Pages 30 : 512 - 519 PubMed Reference 21044762 Abstract Animal models have long been useful in investigating both normal and abnormal human physiology. Systems biology provides a relatively new set of approaches to identify similarities and differences between animal models and human beings that may lead to a more comprehensive understanding of human kidney pathophysiology. In this review, we briefly describe how genome-wide analyses of mouse models have helped elucidate features of human kidney diseases, discuss strategies to achieve effective network integration, and summarize currently available web-based tools that may facilitate integration of data across species. The rapid progress in systems biology and orthology, as well as the advent of web-based tools to facilitate these processes, now make it possible to take advantage of knowledge from distant animal species in targeted identification of regulatory networks that may have clinical relevance for human kidney diseases.

Investigators with authorship
Name Institution Frank Brosius University of Arizona

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing