Understanding kidney disease: toward the integration of regulatory networks
across species.
Authors Ju W, Brosius FC
Submitted By Frank Brosius on 5/2/2011
Status Published
Journal Seminars in nephrology
Year 2010
Date Published 9/1/2010
Volume : Pages 30 : 512 - 519
PubMed Reference 21044762
Abstract Animal models have long been useful in investigating both normal and abnormal
human physiology. Systems biology provides a relatively new set of approaches to
identify similarities and differences between animal models and human beings
that may lead to a more comprehensive understanding of human kidney
pathophysiology. In this review, we briefly describe how genome-wide analyses of
mouse models have helped elucidate features of human kidney diseases, discuss
strategies to achieve effective network integration, and summarize currently
available web-based tools that may facilitate integration of data across
species. The rapid progress in systems biology and orthology, as well as the
advent of web-based tools to facilitate these processes, now make it possible to
take advantage of knowledge from distant animal species in targeted
identification of regulatory networks that may have clinical relevance for human
kidney diseases.

Investigators with authorship
Frank BrosiusUniversity of Arizona