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Publication
An IRKO in the Podo: impaired insulin signaling in podocytes and the
pathogenesis of diabetic nephropathy.
Authors
Gurley SB, Coffman TM
Submitted By
Thomas Coffman on 5/2/2011
Status
Published
Journal
Cell Metabolism
Year
2010
Date Published
10/6/2010
Volume : Pages
12 : 311 - 312
PubMed Reference
20889121
Abstract
Despite its high prevalence, the mechanisms causing diabetic kidney disease
remain poorly understood. In this issue of Cell Metabolism, Welsh et al. (2010)
show that elimination of insulin receptors from the glomerular podocyte, a cell
that is central to the pathogenesis of proteinuric renal diseases, recapitulates
many features of human diabetic nephropathy.
Investigators with authorship
Name
Institution
Thomas Coffman
Duke University Medical Center
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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