How does diabetes accelerate Alzheimer disease pathology?
Authors Sims-Robinson C, Kim B, Rosko A, Feldman EL
Submitted By Eva Feldman on 5/2/2011
Status Published
Journal Nature reviews. Neurology
Year 2010
Date Published 10/1/2010
Volume : Pages 6 : 551 - 559
PubMed Reference 20842183
Abstract Diabetes and Alzheimer disease (AD)-two age-related diseases-are both increasing
in prevalence, and numerous studies have demonstrated that patients with
diabetes have an increased risk of developing AD compared with healthy
individuals. The underlying biological mechanisms that link the development of
diabetes with AD are not fully understood. Abnormal protein processing,
abnormalities in insulin signaling, dysregulated glucose metabolism, oxidative
stress, the formation of advanced glycation end products, and the activation of
inflammatory pathways are features common to both diseases. Hypercholesterolemia
is another factor that has received attention, owing to its potential
association with diabetes and AD. This Review summarizes the mechanistic
pathways that might link diabetes and AD. An understanding of this complex
interaction is necessary for the development of novel drug therapies and
lifestyle guidelines aimed at the treatment and/or prevention of these diseases.

Investigators with authorship
Eva FeldmanUniversity of Michigan