Obesity related kidney disease.
Authors Mathew AV, Okada S, Sharma K
Submitted By Kumar Sharma on 5/2/2011
Status Published
Journal Current diabetes reviews
Year 2011
Date Published 1/1/2011
Volume : Pages 7 : 41 - 49
PubMed Reference 21067508
Abstract Obesity is a risk factor for both de novo disease and as a complication of
existing chronic kidney disease. Obesity related disease is characterized by
albuminuria, glomerulomegaly and secondary focal glomerulosclerosis.
Traditionally altered renal hemodynamics causing hyperfiltration and upregulated
renin angiotensin system have been associated with these changes. Recently
identified circulating factors produced by fat stores such as adiponectin,
leptin and inflammatory markers have shown to directly affect the cells in the
renal glomeruli and cause pathological changes. Weight loss, blockade of the
renin angiotensin system and restoration of adipokine levels may be beneficial
to ameliorate the progression of obesity related disease.

Investigators with authorship
Kumar SharmaUniversity of California San Diego