The New Biology of Diabetic Kidney Disease-Mechanisms and Therapeutic
Authors Lytvyn Y, Bjornstad P, van Raalte DH, Heerspink HL, Cherney DZI
Submitted By Petter Bjornstad on 3/30/2020
Status Published
Journal Endocrine reviews
Year 2020
Date Published 4/1/2020
Volume : Pages 41 : Not Specified
PubMed Reference 31633153
Abstract Diabetic kidney disease remains the most common cause of end-stage kidney
disease in the world. Despite reductions in incidence rates of myocardial
infarction and stroke in people with diabetes over the past 3 decades, the risk
of diabetic kidney disease has remained unchanged, and may even be increasing in
younger individuals afflicted with this disease. Accordingly, changes in public
health policy have to be implemented to address the root causes of diabetic
kidney disease, including the rise of obesity and diabetes, in addition to the
use of safe and effective pharmacological agents to prevent cardiorenal
complications in people with diabetes. The aim of this article is to review the
mechanisms of pathogenesis and therapies that are either in clinical practice or
that are emerging in clinical development programs for potential use to treat
diabetic kidney disease.