Non-uniform gastric wall kinematics revealed by 4D Cine magnetic resonance
imaging in humans.
Authors Sclocco R, Nguyen C, Staley R, Fisher H, Mendez A, Velez C, Kettner NW, Kuo B,
Napadow V
Submitted By Braden Kuo on 4/12/2021
Status Published
Journal Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, REFERENCES
Year 2021
Date Published
Volume : Pages Not Specified : e14146
PubMed Reference 33797166
Abstract Assessment of gastric function in humans has relied on modalities with varying
degrees of invasiveness, which are usually limited to the evaluation of single
aspects of gastric function, thus requiring patients to undergo a number of
often invasive tests for a full clinical understanding. Therefore, the
development of a non-invasive tool able to concurrently assess multiple aspects
of gastric function is highly desirable for both research and clinical
assessments of gastrointestinal (GI) function. Recently, technological advances
in magnetic resonance imaging (MRI) have provided new tools for dynamic (or
"cine") body imaging. Such approaches can be extended to GI applications., In
the present work, we propose a non-invasive assessment of gastric function using
a four-dimensional (4D, volumetric cine imaging), free-breathing MRI sequence
with gadolinium-free contrast enhancement achieved through a food-based meal. In
healthy subjects, we successfully estimated multiple parameters describing
gastric emptying, motility, and peristalsis propagation patterns., Our data
demonstrated non-uniform kinematics of the gastric wall during peristaltic
contraction, highlighting the importance of using volumetric data to derive
motility measures., MRI has the potential of becoming an important clinical and
gastric physiology research tool, providing objective parameters for the
evaluation of impaired gastric function.


Investigators with authorship
NameInstitution
Braden KuoMassachusetts General Hospital

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