| Description |
Mice homozygous for the Nos3 targeted mutation are viable
and fertile. They have elevated blood pressure that is about
20 mmHg higher than that seen in normal wildtype siblings.
They also show a decreased heart rate. Female homozygotes
are smaller in body weight than normal wildtype siblings.
Hyperglycemic-euglycemic clamp studies demonstrate that
homozygotes exhibit insulin resistance at the level of the
liver and peripheral tissues.
|
| Phenotype Description |
Strain Description
Mice homozygous for the Nos3tm1Unc targeted mutation are
viable and fertile. They have elevated blood pressure that
is about 20 mmHg higher than that seen in normal wildtype
siblings. They also show a decreased heart rate. Female
homozygotes are smaller in body weight than normal wildtype
siblings.
|