| Description |
the A/J inbred strain is widely used in cancer and
immunology research. It is highly susceptible to
cortisone-induced congenital cleft palate. It has a high
incidence of spontaneous lung adenomas, and lung tumors
readily develop in response to carcinogens. A high
percentage of mammary adenocarcinomas (a large proportion of
acinar-type) develop in multiparous females.
A/J mice fed an atherogenic diet (1.25% cholesterol, 0.5%
cholic acid, and 15% fat) fail to develop atherosclerotic
aortic lesions in contrast to several highly susceptible
strains of mice (e.g. C57BL/6J, C57L/J, C57BR/cdJ, and
SM/J). In addition to atherosclerosis resistance, A/J mice
are resistant to diabetes, obesity, insulin resistance and
glucose intolerance. On either chow or high fat diet, A/J
mice maintain low glucose and insulin levels.
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