| Description |
FVB/NJ was inbred for the Fv1b allele which confers
sensitivity to the Friend leukemia virus B strain. Due to
the prominent pronuclei in their fertilized eggs and the
large litter size, FVB/NJ mice are commonly used for
transgenic injection. Compared to many other inbred strains,
FVB/NJ is highly susceptible to asthma-like airway
responsiveness with significant generation of
antigen-specific IgE. Despite having the H2q MHC haplotype,
FVB/NJ are resistant to collagen-induced arthritis. This
resistance stems from coding polymorphisms in Tcra-V11.1 and
a genomic deletion of some Tcrb-V genes that includes
Tcrb-V8.2. FVB/NJ have higher than average activity,
anxiety, and basal body temperature, low stress-induced
hyperthermia, and are homozygous for the Pde6brd1 allele,
which results in early onset retinal degeneration. Although
FVB/N typically do not develop spontaneous tumors, they are
highly susceptible to chemically induced squamous cell
carcinomas with a high rate of malignant conversion from
papilloma to carcinoma.
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