| Official Name |
C57BL/6J-Apoe tm1Unc Nos3 tm1Unc |
| Common Name |
C57BL/6J-Apoe -/- Nos3 -/- |
| Description |
Mice homozygous for the Apoe mutation show a marked increase
in total plasma cholesterol levels that are unaffected by
age or sex. Fatty streaks in the proximal aorta are found at
3 months of age. The lesions increase with age and progress
to lesions with less lipid but more elongated cells, typical
of a more advanced stage of pre-atherosclerotic lesion.
Additional studies indicate that apoE-deficient mice have
altered responses to stress, impaired spatial learning and
memory, altered long term potentiation, and synaptic damage.
Mice homozygous for the Nos3 targeted mutation are viable
and fertile. They have elevated blood pressure that is about
20 mmHg higher than that seen in normal wildtype siblings.
They also show a decreased heart rate. Female homozygotes
are smaller in body weight than normal wildtype siblings.
Hyperglycemic-euglycemic clamp studies demonstrate that
homozygotes exhibit insulin resistance at the level of the
liver and peripheral tissues.
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