| Official Name |
C57BL/6J-Ldlrtm1Her Nos3tm1Unc |
| Description |
Mice homozygous for the Ldlrt mutation have an elevated
serum cholesterol level of 200-400 mg/dl and they have very
high levels (>2,000 mg/dl) when fed a high fat diet. Normal
serum cholesterol in the mouse is 80-100 mg/dl. This mutant
mouse strain may be useful in studies of lipid and leptin
homeostasis, hyperglycemia, hypercholesterolemia,
atherosclerosis, and the effects of diet on skin and coat.
Mice homozygous for the Nos3 targeted mutation are viable
and fertile. They have elevated blood pressure that is about
20 mmHg higher than that seen in normal wildtype siblings.
They also show a decreased heart rate. Female homozygotes
are smaller in body weight than normal wildtype siblings.
Hyperglycemic-euglycemic clamp studies demonstrate that
homozygotes exhibit insulin resistance at the level of the
liver and peripheral tissues.
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