DiaComp :: Strain

C57BL/6J-Ldlr^tm1HerLep^ob

Summary

Data Summary

Species	M. musculus
Official Name	C57BL/6J-Ldlr^tm1HerLep^ob
Common Name	C57BL/6J-Ldlr^-/-Lep^ob/ob
Development Status	Breeding ongoing
Creation Method	knockout
Maternal Strain	C57BL/6J-Lep^ob
Paternal Strain	B6.129S7-Ldlr^tm1Her/J
Background	C57BL/6J
Phenotype Description	Leptin deficiency induces pronounced obesity by four weeks of age, hyperinsulinemia, hyperlipidemia, and marked increases in atherosclerosis when coupled with the Ldlr knock out

Type	Count
Investigators	5
Genomics - Modifications	2

Investigators

Name	Institution
E. Dale Abel	University of Iowa
Jan Breslow	Rockefeller University
Firouz Daneshgari	Case Western Reserve
Eva Feldman	University of Michigan
Tim Kern	Case Western Reserve

Genomic Information

Gene	Allele 1	Allele 2	Protocol
Ldlr	knockout	knockout	Not Specified
Lep	point mutation - transition	point mutation - transition	Not Specified

Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:

Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255

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