| Official Name |
B6;129S7-Bdkrb2tm1Jfh/+/JSmi |
| Maternal Strain |
B6.129S7-Bdkrb2tm1Jfh/JSmi |
| Phenotype Description |
These mice are made heterozygous for Bdkrb2 tm1Jfh by
crossing to B6.
Mice that are homozygous for the targeted disruption of the
gene encoding the B2 bradykinin receptor have been
generated. The gene disruption results in a deletion of the
entire coding sequence for the B2 receptor. The disruption
of the B2 receptor gene has been confirmed by genetic,
biochemical, and pharmacological analyses. Mice that are
homozygous for the disruption of the B2 receptor gene are
fertile and indistinguishable from their littermates by
visual inspection. Bradykinin fails to produce responses in
pharmacological preparations from ileum, uterus, and the
superior cervical ganglia from these mice. Therefore,
expression of a single gene appears to be responsible for
conferring responsiveness to bradykinin in these tissues.
|