| Official Name |
C57BL/6J-Ins2Akita/+ Bdkrb2tm1Jfh /JSmi |
| Description |
Mice homozygous for this targeted mutation of the bradykinin
receptor, beta 2 (Bdkrb2) gene and heterozygous for the
Akita spontaneous mutation of the insulin 2 (Ins2) gene
(Ins2 Akita) are viable and fertile. They are extremely
diabetic, underweight, hyperphagic, polyuric, and have
severe kidney, skeletal, and testicular defects. essentially
no subcutaneous fat, and a significantly reduced lifespan.
This strain may be used to research the kallikrein-kinin
system, specifically the role of bradykinin B2 receptor in
diabetes, oxidative stress, mitochondrial DNA damage,
apoptosis, kidney morphology and function, and other
senescence-associated phenotypes.
|
| Paternal Strain |
B6.129S7-Bdkrb2tm1Jfh/JSmi |