| Description |
BALB/C mouse where the thromboxane A2 receptor gene has been
knocked out. The insertion of a PGK-neo cassette into exon 2
disrupted sequence encoding the third transmembrane domain.
Though Northern blot analysis identified several aberrant
transcripts in homozygous mutant mice, no normal transcript
was detected. Binding assays using a labeled thromboxane
agonist indicated an absence of functional receptors in both
thymocytes and renal sections obtained from homozygous
mutant mice
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