DiaComp :: Strain

C57BL/6J-Lep^ob

Summary

Data Summary

Species	M. musculus
Official Name	C57BL/6J-Lep^ob
Common Name	C57BL/6J ^ob/ob
Description	Sequencing of RT-PCR products revealed a nonsense mutation in codon 105 resulting from a C to T point mutation. The 16 kDa leptin protein, expressed predominantly in adipose tissue of normal mice, is missing from homozygous mutant mice
Development Status	Not specified/Other
Creation Method	spontaneous
Maternal Strain	C57BL/6J
Paternal Strain	C57BL/6J
Background	C57BL/6J
Breeding Type	intercross

Type	Count
Genomics - Modifications	1
Child Strains	1

Genomic Information

Gene	Allele 1	Allele 2	Protocol
Lep	point mutation - transition	point mutation - transition	Not Specified

Child Strains

Strain	Species	Development Status	Creation Method
C57BL/6J-Ldlr^tm1HerLep^ob [Consortial]		Breeding ongoing	knockout

Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:

Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255

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