| Official Name |
B6.129-Ins2Akita Bdkrb2tm1Jfh/SmiJ |
| Description |
Mice homozygous for this targeted mutation of the bradykinin
receptor, beta 2 (Bdkrb2) gene and heterozygous for the
Akita spontaneous mutation of the insulin 2 (Ins2) gene (Ins2)
viable and fertile. They are extremely diabetic,
underweight, hyperphagic, polyuric, and have severe kidney,
skeletal, and testicular defects. essentially no
subcutaneous fat, and a significantly reduced lifespan. This
strain may be used to research the kallikrein-kinin system,
specifically the role of bradykinin B2 receptor in diabetes,
oxidative stress, mitochondrial DNA damage, apoptosis,
kidney morphology and function, and other
senescence-associated phenotypes.
|