| Official Name |
129B6F1.Cg-Ins2Akita Nos3tm1Unc/J |
| Common Name |
129B6F1.Cg-Ins2Akita Nos3tm1Unc/J |
| Description |
F1 cross between 129 and B6 with the Akita mutation and Nos3
KO. Mice homozygous for the Nos3 targeted mutation are
viable and fertile. They have elevated blood pressure that
is about 20 mmHg higher than that seen in normal wildtype
siblings. They also show a decreased heart rate. Female
homozygotes are smaller in body weight than normal wildtype
siblings. Hyperglycemic-euglycemic clamp studies demonstrate
that homozygotes exhibit insulin resistance at the level of
the liver and peripheral tissues.
|